Advanced Treatment for Chronic Wounds & Severe Burns
Extensive burns and full thickness skin wounds can be devastating to patients, even when treated.
Recent advances in tissue engineering have led to more complex biological skin equivalents that may yield more suitable wound treatment options for patients. These products are generally comprised of a polymer scaffold patch that is seeded with human fibroblasts and cultured in vitro prior to application. Unfortunately, these grafts are also expensive to produce, and similar to allografts, have the same immunological drawbacks.
The tissue source used in wound care is an important consideration that has implications for the cost, quality of healing, and natural outcome of the treatments. However autologous allogenic tissue suffers from the same drawbacks as their autologous and allogenic graft counterparts; i.e. secondary surgical sites and potential for rejection, respectively. Furthermore, human tissue therapies have complicated regulatory and financial hurdles to overcome prior to commercialization.
Thus, there is a need for quickly prepared wound healing products that have high clinical benefit. Our product candidates satisfy this unmet need.
Features and Benefits of BIOHEAL THERAPEUTICS BioHeal® Hydrogel - XG100 Product Candidate Processed Using the Proprietary & Patented BioHeal Matrix™ Technology
|Tissue processed using BioHeal Matrix™
Technology (BMT) does not undergo a decellularization process as part of the product production
|Research has shown that the cells are a valuable source of pro-healing and regenerative components that are lost with the removal of cells (see supporting bibliography on Technology Page)|
|BioHeal does not contain living cells||BMT tissue processing utilizes the complete amniotic tissue that are digested and preserved into the hydrogel, maintaining their functional collagen matrix, but without the challenges of maintaining and storing a living cell or tissue product (see supporting bibliography on Technology Page)|
|Wound closure and re-epithelialization||Large animal research shows improvement over existing cleared amnion based products (see supporting bibliography on Technology Page)|
|Processed to maintain natural healing collagen matrix proteins||Provides optimal cosmetic outcomes compared to other more expensive polymer scaffolds (see supporting bibliography on Technology Page)|
|Ease of use & room temperature storage||Mixes in a few minutes, no hydrating or thawing. Off-the-shelf, no need for cryopreservation storage. Delivered in a hydrating and protective hydrogel carrier that helps functional healthy skin (see supporting bibliography on Technology Page)|
|Ease of handling & effective coverage of partial, full thickness, irregular, and deep wounds||No suturing. No supply issues, unlike allograft skin that is supply limited. Wound dressing that covers dry, light and moderately exudating partial and full thickness (first and second-degree burns, severe sunburns, and superficial injuries, cuts, abrasions and surgical wounds), irregular shaped and deep wounds (see supporting bibliography on Technology Page)|
|Sterilized amnion tissue||No immune response, unlike allograft skin which requires immunosuppressive drugs (see supporting bibliography on Technology Page)|